Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS313) and contralateral breast cancer (CBC) risk.


Due to the high incidence of breast cancer and improving survival, an increasing number of breast cancer survivors are at risk of developing contralateral breast cancer (CBC). The 10-year cumulative incidence of CBC is ∼4%, 1

The primary  For breast cancer patients, the average lifetime risk of developing a new breast cancer in the opposite breast is low, ranging from 4 to 8%, and is even lower in  Approximately half of breast cancers can be explained by known risk factors, like Breast Cancer Family History and Contralateral Breast Cancer Risk in Young  31 Mar 2021 No evidence was found that RT further elevated CBC risk in young women with first primary breast cancer who were current smokers or had a  15 Nov 2012 While contralateral breast cancer is the most common malignancy among breast cancer survivors, it is still incredibly rare. The risk figure usually  30 Dec 2015 Among women diagnosed with breast cancer, the risk of developing a second primary asynchronous contralateral breast cancer (CBC) is greater  6 Oct 2016 Adjuvant Endocrine Therapy and Risk of Contralateral Breast Cancer · This video is either unavailable or not supported in this browser · Adjuvant  17 Oct 2014 Therefore, the analysis of CBC is becoming an important public issue. The overall incidence rates of CBC vary between 4 and 8 per 1,000  21 Jun 2017 “Generally, what we've been telling patients is that the risk of developing cancer in the contralateral breast is very low, about 6% over 10 years,  13 Jan 2020 BRCA1 and BRCA2 mutation patients had a respective 4.5- and 3.4-fold elevated risk of developing contralateral breast cancer (17). Previous  19 Mar 1992 Patients with breast cancer have a threefold increase in the risk that a second breast cancer will develop. Radiation treatment for the initial cancer  19 Oct 2016 Bethesda, MD—The risk of developing an additional malignant tumor in the About 5% of patients develop contralateral breast cancer (CBC)  11 Feb 2014 Our previous research has shown that women with a BRCA1 or BRCA2 mutation have a high risk of developing subsequent cancer in the  28 Apr 2017 They evaluated outcomes in terms of CBC (defined as either DCIS or invasive cancer) as well as the rates of CBC compared with the rates of  Risk of Contralateral Breast Cancer Among Women with Carcinoma In Situ of the Breast. Habel, Laurel A. M.P.H.

Contralateral breast cancer risk

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T1 - Risks for familial and contralateral breast cancer interact multiplicatively and cause a high risk. AU - Hemminki, Kari. AU - Ji, Jianguang. Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk. NBCS Collaborators, ABCTB Investigators , kConFab Investigators  Bekanta dig med närmare uppgifter om publikationen i av S Gottlieb · 2001 — The researchers identified contralateral breast cancers in 89 of the tamoxifen users and 100 of the non-users.

Risk of Contralateral Breast Cancer in Women with and without Pathogenic Variants in BRCA1, BRCA2, and TP53 Genes in Women with Very Early-Onset (<36 

Prophylactic surgery to remove a contralateral breast during breast cancer surgery (known as contralateral prophylactic mastectomy) reduces the risk of breast cancer in that breast (2,4,5,13), although it is not yet known whether this risk reduction translates into longer survival for the patient . Prediction and clinical utility of a contralateral breast cancer risk model Abstract. Breast cancer survivors are at risk for contralateral breast cancer (CBC), with the consequent burden of Introduction. Breast cancer (BC) is a major burden for women’s health [ 1 ].

Relative Risk (RR) of the Development of Contralateral Breast Cancer among Women Exposed to Various Doses of Radiation, According to Age at Exposure and Time after Exposure.*

bedömning Tumor stage affects risk and prognosis of contralateral breast cancer: results from  Publikation: “High Risk of Contralateral Breast Cancer in Women with Hereditary/Familial non-BRCA1/BRCA2 Breast Cancer,” K. Shahedi,  Fokus låg på en faktor, AIB1 (amplified in breast cancer 1), som aktiverar östrogenreceptorerna i En hög nivå av AIB1 innebär ökad risk för återfall och kortare livslängd. With a special focus on contralateral breast cancer. to immune-surveillance and risk of cancer development. Anslag beviljat: Hartman, Carl Johan Henning - Refining breast cancer diagnostics through precision clinically normal tongue contralateral to the tumour. Anslag  Cancergenetisk utredning vid misstänkt bröstcancerrisk, mutationsscreening .

Cancer Contralateral Prophylactic Mastectomy in Invasive Lobular. Carcinoma. EUSOMA – European Society of Breast Cancer Specialists, definierar receptor status in relation to risk of contralateral breast cancer- a  Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2. Mutation Carriers. Jama. 2017;317(23):2402-16.
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Granader, E.J., Dwamena, B. & Carlos, R.C. (2008).

A  AIM: To identify differences in the incidence of contralateral breast cancer between patients with a primary tumour diagnosis of invasive ductal carcinoma ( IDC)  20 Jun 2017 For contralateral breast cancer, the cumulative risk 20 years after breast cancer diagnosis was 40% (95% CI, 35%-45%) for BRCA1 and 26% (95  1 Mar 2020 BACKGROUND: Increasingly, patients with breast cancer undergo bilateral mastectomy (BLM). To the authors' knowledge, the magni- tude of  Prophylactic Mastectomy Among Women With Unilateral Breast.
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Breast cancer patients who are identified as carrying a BRCA1/2 mutation are amongst those at highest risk of developing a contralateral breast cancer. Mainstream genetic testing has the potential unravel more breast cancer patients who harbour such a genetic mutation.

in the UPJO kidney compared with the nonobstructed contralateral kidney. Recension av Påverka din cancerrisk 56 46 Elisabet Lidbrink och Må “Effects of chemotherapy and hormonal therapy for early breast cancer on (lokalt återfall, metastatisk sjukdom och contralateral bröstcancer, HR  Barn som har en relativ viktökning redan då har en påtaglig risk att sedan vara in the deepest possible portion and then again the contralateral, right side fascia. for women for breast augmentation when not associated with breast cancer.

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The risk of contralateral breast cancer is higher for daughters of breast cancer patients than for daughters of women without breast cancer. Maternal cancer history and age at onset of first breast cancer in women should be taken into account when counseling breast cancer patients about their risk of contralateral breast cancer.